Cancer incidence is increasing more rapidly and cancer survival is worse among Ontario’s First Nations, Inuit and Métis populations than among other Ontarians. Cancer Care Ontario’s Aboriginal Cancer Strategy II aims to reduce this health inequity and to improve the cancer journey and experience for First Nations, Inuit and Métis people in Ontario. This comprehensive, multi-faceted strategy was developed, and is being implemented with and for Aboriginal Peoples in Ontario in a way that honours the Aboriginal Path of well-being.